• How Digital Chemistry Will Improve Cross-Functional Collaboration In The Biopharma Industry

    Nov 22 | Bio-IT World | Digital chemistry is the term given to recent developments in using digital control and big data approaches for designing molecules, optimizing and controlling chemical reactions, and performing complex chemical processes under digital control with sensor feedback. A fundamental development in digital chemistry is the evolution of the concept of chemputation, which allows chemical reactions to be easily done robotically using a general purpose programming language for chemical synthesis. More

  • ‘Secret Shares’ of Patient Health Data Enable Secure Multiparty Research

    Nov 20 | Bio-IT World | Scientists in Europe collaborated on the first international-level clinical study using secure multiparty computation (MPC), which enabled cross-border cooperation without sharing any personalized health data. The cryptographic method traces back to the late 1970s but has been “severely underused” up until now because it’s computationally complex and few data security experts are familiar with the technology. More

  • Recursion, Novo Nordisk Release New Chemistry Foundation Model

    Nov 19 | Bio-IT World | In a paper published last week in Nature Communications, teams from Recursion and Novo Nordisk created a new foundation model for chemistry called MolE. Benchmarked for absorption, distribution, metabolism, excretion, and toxicity (ADMET) using the Therapeutic Data Commons, MolE outperformed previous models. More

  • Much Like a Crime Scene, Cancer’s Evolution Can be Reconstructed

    Nov 14 | Bio-IT World | Investigators at Weill Cornell Medicine have combined several powerful technologies to reconstruct how cancer spreads from the prostate to metastatic sites elsewhere in the body. Bioluminescence imaging, CRISPR/Cas9-based barcoding, and innovative computational methods for tracing the movement of cancer from tissue to tissue were used in creating a roadmap revealing the small number of aggressive cells that seed cancer’s often deadly migration. More

  • Blueprint of the Human Spliceosome Could Help Find Cancer’s Achilles’ Heel

    Nov 13 | Bio-IT World | The spliceosome, the cellular machinery that catalyzes the process of splicing in genes, was discovered nearly five decades ago and has been successfully leveraged in the development of therapies for rare diseases such as spinal muscular dystrophy where concerns about side effects tend to be secondary to correcting the underlying pathology. The question now is how to move the strategy to more complex diseases involving more than a single gene and splicing mutation. More

  • New Diagnostic Tool for Identifying the Effects of Antifibrotic Therapy in Breast Cancer

    Nov 12 | Bio-IT World | In recent research, scientists at the University of Arizona have developed a diagnostic tool, the MeCo Score, which evaluates metastatic risk in early-stage breast cancer by analyzing how cancer cells respond to the stiffness of surrounding tissue. This tool leverages RNA sequencing data from tumor samples to identify a "mechanical conditioning" (MeCo) signature, giving insights into cancer cell adaptations within the tumor microenvironment. More

  • Foundations for Change: A Framework for Transforming R&D Outcomes With AI

    Nov 08 | Bio-IT World | For AI and data-driven drug discovery to have a tangible impact on R&D success, a change in the culture is as important as any investment at a data, model, and validation level. Until quite recently, the perceived value of AI in drug discovery and development failed to match the hype. More

  • PacBio’s Pink Desktop Platform, $500 Genome Chemistry

    Nov 07 | Bio-IT World | This week at the American Society of Human Genetics meeting, Pacific Biosciences unveiled both its new SPRQ chemistry—pronounced “spark”— and its newest sequencing platform, Vega, a desktop, long-read sequencer with all the compute on board. Also it’s pink. More

  • New Data Suggests a More Expansive View of Heart Health Lipids

    Nov 04 | Bio-IT World | The traditional LDL and HDL cholesterol tests may soon be obsolete as new research suggests they provide an incomplete view of heart health compared to other lipid molecules circulating in the blood. This shift stems from a recent study led by Dr. Cristina Legido-Quigley, a systems medicine expert at King’s College London and Steno Diabetes Centre, which analyzed lipids in children with obesity. More

  • AI Points to Drug Repurposing Opportunities for Diseases Without Cures

    Oct 31 | Bio-IT World | Harvard scientists have succeeded in using artificial intelligence (AI) to identify promising drug candidates for diseases for which there are no examples of successful treatment. The graph foundation model, known as TxGNN, opens untold opportunities to repurpose drugs for the thousands of diseases afflicting small populations and exacting a huge toll in terms of both economics and human suffering. More
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